I think once a user gets to that size or more of hosts they typically look at tools like ansible/chef/puppet to do configuration management.
I’m at this point myself (8-10 servers i had been managing by custom scripts) but need to now look into learning Ansible and use that tool to solve these issues.
We have an example doc here for Ansible: Deploy Netdata with Ansible | Learn Netdata
I’m hoping to try and create more material to share with the community as i learn Ansible for netdata myself since its completely new to me.
Here is an example twitch stream i found interesting where a user is using Chef to do the configuration management on a fleet of servers. [2021-05-12] Refactoring the Chef cookbook for Netdata - YouTube
So currently i believe the answer is to use a tool like ansible/chef/puppet to automate the configuration management of your netdata agents.
We do have future plans to maybe have some way to do some centralized agent configuration from within Netdata Cloud but thats still a bit far out from what i can see.